Sikeston, Missouri
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Sikeston is a city in Scott and New Madrid Counties, Missouri (though mostly in Scott). Its population was 16,318 at the 2010 census, making it one of the largest cities in Southeast Missouri.
Because of its location, approximately halfway between St. Louis and Memphis, and at the intersection of several major national highways, Sikeston is considered something of a gateway to the South. It is often included as part of the Missouri "Bootheel".