Talk:Hydroxychloroquine

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Making a distinction

Are Hydroxychloroqine (C18H26ClN3O) and hydroxychloroquine sulfate the same chemical?

  • In other words, two names for exactly the same drug; or,
  • Two slightly different drugs - maybe one has a few sulfur atoms in it

Just asking. --Ed Poor Talk 20:58, 2 July 2020 (EDT)

I'm thinking that C18H28ClN3O5S is a slightly different chemical compound. --Ed Poor Talk 21:01, 2 July 2020 (EDT)

HCQ vindicated

Finally, a test of the Zelenko drug combo -- and it seems to work: "Media Should Do a Mea Culpa as French Analysis Offers a Stunning Observation About Hydroxychloroquine Use." PeterKa (talk) 10:38, 17 July 2020 (EDT)

Meta-analysis of studies

Hydroxychloroquine has no statistically significant effect on covid survival rates, with or without azithromycin. That's according to a "Bayesian meta-analysis" of published HCQ studies. See "Effect of hydroxychloroquine with or without azithromycin on the mortality of COVID-19 patients: a systematic review and meta-analysis." The authors have mathematically combined the published HCQ studies into an enormous meta-study with 11,932 patients in the HCQ group, 8,081 in the HCQ with azithromycin group, and 12,930 in the control group. Taking HCQ with azithromycin is bad news. It results in a 27 percent higher mortality. Combining 15 published studies suggests that HCQ increases a covid patient's chance of survival by 17 percent. Using just the three randomized studies suggests a 9 percent decrease in the survival rate. Neither of these results is statistically significant.

According to this article, there two redundant pathways that allow the virus to enter a cell. HCQ blocks only one of these pathways, so it won't work by itself. Will zinc block the other pathway? The study I cited in the previous section suggests that it might. PeterKa (talk) 04:15, 1 September 2020 (EDT)