Megakaryocyte - Revision history

DavidB4-bot: /* top */Spelling, Grammar, and General Cleanup, typos fixed: psuedopodia → pseudopodia

2016-07-11T17:44:06Z

top: Spelling, Grammar, and General Cleanup, typos fixed: psuedopodia → pseudopodia

RobSmith: Reverted edits by ImVeryGay (Talk) to last version by TerryH

2010-03-01T13:30:25Z

Reverted edits by ImVeryGay (Talk) to last version by TerryH

ImVeryGay at 12:47, March 1, 2010

2010-03-01T12:47:55Z

TerryH: Reverted edits by IblannkPAGES (Talk) to last version by Ed Poor

2009-11-15T13:21:24Z

Reverted edits by IblannkPAGES (Talk) to last version by Ed Poor

IblannkPAGES: Blanked the page

2009-11-15T13:04:53Z

Blanked the page

Ed Poor at 21:36, December 31, 2007

2007-12-31T21:36:16Z

GregLarson: categorize

2007-11-02T20:05:41Z

categorize

Ehdrive: New page: The '''megakaryocyte''' is a large cell in the bone marrow that creates platelets by fragmenting into small, odd-shaped pieces. These fragments (platelets) ...

2007-11-02T19:41:22Z

New page: The '''megakaryocyte''' is a large cell in the bone marrow that creates platelets by fragmenting into small, odd-shaped pieces. These fragments (platelets) ...

New page

The '''megakaryocyte''' is a large [[cell (biology)|cell]] in the [[bone marrow]] that creates [[platelet]]s by fragmenting into small, odd-shaped pieces. These fragments ([[platelet]]s) of the megakaryocyte's [[cytoplasm]] circulate in the blood as the body's first line of defense against blood loss, a process that is called [[hemostasis]]. This article will discuss how megakaryocytes give rise to platelets, as well as how megakaryocytes themselves arise from less differentiated cells, and how they mature.

The [[bone marrow]] is a compartment inside some of the bones of [[vertebrates]], including humans, that contains important [[stem cells]] that go on to make up all the cellular elements of the circulating [[blood]] and some of the cells of the [[immune system]] that live in the solid organs of the [[reticuloendothelium system]].

DNA synthesis is occuring in the nucleus during thrombopoiesis (stimulated by thrombopoietin) without cytokenesis, aka endoreduplication. Therefore, the nucleus of the megakaryocyte can become very large and lobulated, which, under a light microscope, can give the false impression that there are several nuclei. In some cases, the nucleus may contain up o 64N DNA.

Platelets are held within demarcation channels, internal membranes within the cytoplasm of megakaryocytes. Megakaryocytes release their platelets in one of two ways. The cell may release its platelets by rupturing and releasing its contents all at once in the marrow. Alternatively, the cell may form platelet ribbons into blood vessels. The ribbons are formed via psuedopodia and they are able to continuously emit platelets into circulation. 2/3 of these platelets will remain in circulation while 1/3 will be sequestered by the spleen.

''Megakaryocyte'' function is determined by a large number of [[cytokine]]s, including [[thrombopoietin]].

The developmental stages of the megakaryocyte is:
CFU-Me ([[pluripotential hemopoietic stem cell]] or hemocytoblast) -> [[megakaryoblast]] -> promegakaryocyte -> megakaryocyte.

@@ Line 7: / Line 7: @@
 DNA synthesis is occurring in the nucleus during thrombopoiesis (stimulated by thrombopoietin) without cytokenesis, aka endoreduplication.  Therefore, the nucleus of the megakaryocyte can become very large and lobulated, which, under a light microscope, can give the false impression that there are several nuclei.  In some cases, the nucleus may contain up o 64N DNA.
-Platelets are held within demarcation channels, internal membranes within the cytoplasm of megakaryocytes.  Megakaryocytes release their platelets in one of two ways.  The cell may release its platelets by rupturing and releasing its contents all at once in the marrow.  Alternatively, the cell may form platelet ribbons into blood vessels.  The ribbons are formed via psuedopodia and they are able to continuously emit platelets into circulation.  2/3 of these platelets will remain in circulation while 1/3 will be sequestered by the spleen.
+Platelets are held within demarcation channels, internal membranes within the cytoplasm of megakaryocytes.  Megakaryocytes release their platelets in one of two ways.  The cell may release its platelets by rupturing and releasing its contents all at once in the marrow.  Alternatively, the cell may form platelet ribbons into blood vessels.  The ribbons are formed via pseudopodia and they are able to continuously emit platelets into circulation.  2/3 of these platelets will remain in circulation while 1/3 will be sequestered by the spleen.
 ''Megakaryocyte'' function is determined by a large number of [[cytokine]]s, including [[thrombopoietin]].

← Older revision		Revision as of 13:30, March 1, 2010
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−	PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS	+	The '''megakaryocyte''' is a large [[cell (biology)\|cell]] in the [[bone marrow]] that creates [[platelet]]s by fragmenting into small, odd-shaped pieces. These fragments ([[platelet]]s) of the megakaryocyte's [[cytoplasm]] circulate in the blood as the body's first line of defense against blood loss, a process that is called [[hemostasis]].
		+
		+	This article will discuss how megakaryocytes give rise to platelets, as well as how megakaryocytes themselves arise from less differentiated cells, and how they mature.
		+
		+	The [[bone marrow]] is a compartment inside some of the bones of [[vertebrates]], including humans, that contains important [[stem cells]] that go on to make up all the cellular elements of the circulating [[blood]] and some of the cells of the [[immune system]] that live in the solid organs of the [[reticuloendothelium system]].
		+
		+	DNA synthesis is occurring in the nucleus during thrombopoiesis (stimulated by thrombopoietin) without cytokenesis, aka endoreduplication. Therefore, the nucleus of the megakaryocyte can become very large and lobulated, which, under a light microscope, can give the false impression that there are several nuclei. In some cases, the nucleus may contain up o 64N DNA.
		+
		+	Platelets are held within demarcation channels, internal membranes within the cytoplasm of megakaryocytes. Megakaryocytes release their platelets in one of two ways. The cell may release its platelets by rupturing and releasing its contents all at once in the marrow. Alternatively, the cell may form platelet ribbons into blood vessels. The ribbons are formed via psuedopodia and they are able to continuously emit platelets into circulation. 2/3 of these platelets will remain in circulation while 1/3 will be sequestered by the spleen.
		+
		+	''Megakaryocyte'' function is determined by a large number of [[cytokine]]s, including [[thrombopoietin]].
		+
		+	The developmental stages of the megakaryocyte is:
		+	CFU-Me ([[pluripotential hemopoietic stem cell]] or hemocytoblast) -> [[megakaryoblast]] -> promegakaryocyte -> megakaryocyte.
		+
		+	[[Category:Biology]]

← Older revision		Revision as of 12:47, March 1, 2010
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−	The '''megakaryocyte''' is a large [[cell (biology)\|cell]] in the [[bone marrow]] that creates [[platelet]]s by fragmenting into small, odd-shaped pieces. These fragments ([[platelet]]s) of the megakaryocyte's [[cytoplasm]] circulate in the blood as the body's first line of defense against blood loss, a process that is called [[hemostasis]].	+	PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS PENIS
−
−	~~This article will discuss how megakaryocytes give rise to platelets, as well as how megakaryocytes themselves arise from less differentiated cells, and how they mature.~~
−
−	The [[bone marrow]] is a compartment inside some of the bones of [[vertebrates]], including humans, that contains important [[stem cells]] that go on to make up all the cellular elements of the circulating [[blood]] and some of the cells of the [[immune system]] that live in the solid organs of the [[reticuloendothelium system]].
−
−	DNA synthesis is occurring in the nucleus during thrombopoiesis (stimulated by thrombopoietin) without cytokenesis, aka endoreduplication. Therefore, the nucleus of the megakaryocyte can become very large and lobulated, which, under a light microscope, can give the false impression that there are several nuclei. In some cases, the nucleus may contain up o 64N DNA.
−
−	Platelets are held within demarcation channels, internal membranes within the cytoplasm of megakaryocytes. Megakaryocytes release their platelets in one of two ways. The cell may release its platelets by rupturing and releasing its contents all at once in the marrow. Alternatively, the cell may form platelet ribbons into blood vessels. The ribbons are formed via psuedopodia and they are able to continuously emit platelets into circulation. 2/3 of these platelets will remain in circulation while 1/3 will be sequestered by the spleen.
−
−	~~''Megakaryocyte'' function is determined by a large number of [[cytokine]]s, including [[thrombopoietin]].~~
−
−	~~The developmental stages of the megakaryocyte is:~~
−	~~CFU-Me ([[pluripotential hemopoietic stem cell]] or hemocytoblast) -> [[megakaryoblast]] -> promegakaryocyte -> megakaryocyte.~~
−
−	~~[[Category:Biology]]~~

← Older revision		Revision as of 13:04, November 15, 2009
Line 1:		Line 1:
−	The '''megakaryocyte''' is a large [[cell (biology)\|cell]] in the [[bone marrow]] that creates [[platelet]]s by fragmenting into small, odd-shaped pieces. These fragments ([[platelet]]s) of the megakaryocyte's [[cytoplasm]] circulate in the blood as the body's first line of defense against blood loss, a process that is called [[hemostasis]].

−	~~This article will discuss how megakaryocytes give rise to platelets, as well as how megakaryocytes themselves arise from less differentiated cells, and how they mature.~~
−
−	The [[bone marrow]] is a compartment inside some of the bones of [[vertebrates]], including humans, that contains important [[stem cells]] that go on to make up all the cellular elements of the circulating [[blood]] and some of the cells of the [[immune system]] that live in the solid organs of the [[reticuloendothelium system]].
−
−	DNA synthesis is occurring in the nucleus during thrombopoiesis (stimulated by thrombopoietin) without cytokenesis, aka endoreduplication. Therefore, the nucleus of the megakaryocyte can become very large and lobulated, which, under a light microscope, can give the false impression that there are several nuclei. In some cases, the nucleus may contain up o 64N DNA.
−
−	Platelets are held within demarcation channels, internal membranes within the cytoplasm of megakaryocytes. Megakaryocytes release their platelets in one of two ways. The cell may release its platelets by rupturing and releasing its contents all at once in the marrow. Alternatively, the cell may form platelet ribbons into blood vessels. The ribbons are formed via psuedopodia and they are able to continuously emit platelets into circulation. 2/3 of these platelets will remain in circulation while 1/3 will be sequestered by the spleen.
−
−	~~''Megakaryocyte'' function is determined by a large number of [[cytokine]]s, including [[thrombopoietin]].~~
−
−	~~The developmental stages of the megakaryocyte is:~~
−	~~CFU-Me ([[pluripotential hemopoietic stem cell]] or hemocytoblast) -> [[megakaryoblast]] -> promegakaryocyte -> megakaryocyte.~~
−
−	~~[[Category:Biology]]~~

← Older revision		Revision as of 20:05, November 2, 2007
Line 11:		Line 11:
	The developmental stages of the megakaryocyte is:		The developmental stages of the megakaryocyte is:
	CFU-Me ([[pluripotential hemopoietic stem cell]] or hemocytoblast) -> [[megakaryoblast]] -> promegakaryocyte -> megakaryocyte.		CFU-Me ([[pluripotential hemopoietic stem cell]] or hemocytoblast) -> [[megakaryoblast]] -> promegakaryocyte -> megakaryocyte.
		+
		+	[[Category:Biology]]

← Older revision	Revision as of 13:21, November 15, 2009
Line 1:	Line 1:
	+	The '''megakaryocyte''' is a large [[cell (biology)\|cell]] in the [[bone marrow]] that creates [[platelet]]s by fragmenting into small, odd-shaped pieces. These fragments ([[platelet]]s) of the megakaryocyte's [[cytoplasm]] circulate in the blood as the body's first line of defense against blood loss, a process that is called [[hemostasis]].

	+	This article will discuss how megakaryocytes give rise to platelets, as well as how megakaryocytes themselves arise from less differentiated cells, and how they mature.
	+
	+	The [[bone marrow]] is a compartment inside some of the bones of [[vertebrates]], including humans, that contains important [[stem cells]] that go on to make up all the cellular elements of the circulating [[blood]] and some of the cells of the [[immune system]] that live in the solid organs of the [[reticuloendothelium system]].
	+
	+	DNA synthesis is occurring in the nucleus during thrombopoiesis (stimulated by thrombopoietin) without cytokenesis, aka endoreduplication. Therefore, the nucleus of the megakaryocyte can become very large and lobulated, which, under a light microscope, can give the false impression that there are several nuclei. In some cases, the nucleus may contain up o 64N DNA.
	+
	+	Platelets are held within demarcation channels, internal membranes within the cytoplasm of megakaryocytes. Megakaryocytes release their platelets in one of two ways. The cell may release its platelets by rupturing and releasing its contents all at once in the marrow. Alternatively, the cell may form platelet ribbons into blood vessels. The ribbons are formed via psuedopodia and they are able to continuously emit platelets into circulation. 2/3 of these platelets will remain in circulation while 1/3 will be sequestered by the spleen.
	+
	+	''Megakaryocyte'' function is determined by a large number of [[cytokine]]s, including [[thrombopoietin]].
	+
	+	The developmental stages of the megakaryocyte is:
	+	CFU-Me ([[pluripotential hemopoietic stem cell]] or hemocytoblast) -> [[megakaryoblast]] -> promegakaryocyte -> megakaryocyte.
	+
	+	[[Category:Biology]]

@@ Line 1: / Line 1: @@
-The '''megakaryocyte''' is a large [[cell (biology)|cell]] in the [[bone marrow]]  that creates [[platelet]]s by fragmenting into small, odd-shaped pieces. These fragments ([[platelet]]s) of the megakaryocyte's [[cytoplasm]] circulate in the blood as the body's first line of defense against blood loss, a process that is called [[hemostasis]]. This article will discuss how megakaryocytes give rise to platelets, as well as how megakaryocytes themselves arise from less differentiated cells, and how they mature.
+The '''megakaryocyte''' is a large [[cell (biology)|cell]] in the [[bone marrow]]  that creates [[platelet]]s by fragmenting into small, odd-shaped pieces. These fragments ([[platelet]]s) of the megakaryocyte's [[cytoplasm]] circulate in the blood as the body's first line of defense against blood loss, a process that is called [[hemostasis]].
 The [[bone marrow]] is a compartment inside some of the bones of [[vertebrates]], including humans, that contains important [[stem cells]] that go on to make up all the cellular elements of the circulating [[blood]] and some of the cells of the [[immune system]] that live in the solid organs of the [[reticuloendothelium system]].
-DNA synthesis is occuring in the nucleus during thrombopoiesis (stimulated by thrombopoietin) without cytokenesis, aka endoreduplication.  Therefore, the nucleus of the megakaryocyte can become very large and lobulated, which, under a light microscope, can give the false impression that there are several nuclei.  In some cases, the nucleus may contain up o 64N DNA.
+DNA synthesis is occurring in the nucleus during thrombopoiesis (stimulated by thrombopoietin) without cytokenesis, aka endoreduplication.  Therefore, the nucleus of the megakaryocyte can become very large and lobulated, which, under a light microscope, can give the false impression that there are several nuclei.  In some cases, the nucleus may contain up o 64N DNA.
 Platelets are held within demarcation channels, internal membranes within the cytoplasm of megakaryocytes.  Megakaryocytes release their platelets in one of two ways.  The cell may release its platelets by rupturing and releasing its contents all at once in the marrow.  Alternatively, the cell may form platelet ribbons into blood vessels.  The ribbons are formed via psuedopodia and they are able to continuously emit platelets into circulation.  2/3 of these platelets will remain in circulation while 1/3 will be sequestered by the spleen.