A strong supporter of [[Franklin D. Roosevelt]] and New Deal programs during the [[Great Depression]], Murray stayed loyal to the president even during the 1937 [[court packing]] attempt.<ref name=knoxvillefocus/> Unlike his Democrat colleague [[Burton K. Wheeler]] from the state's Class I seat,<ref name=archives/> he never significantly broke with Roosevelt, though ultimately did vote to recommit the Judicial Procedures Reform Bill for committee.<ref>[https://www.govtrack.us/congress/votes/75-1/s42 TO RECOMMIT TO THE COMMITTEE ON THE JUDICIAL BRANCH OF GOVERNMENT. S. 1392, A BILL TO REORGANIZE THE JUDICIARY BRANCH.]. ''GovTrack.us''. Retrieved August 2, 2021.</ref>
In 1942 when the U.S. became involved in [[World War II]] following the [[attack on Pearl Harbor]], Murray was the only member of Congress from his state to support Roosevelt's [[foreign policy]];<ref>FascinatingPolitics (February 23, 2020). [https://fascinatingpolitics.com/2020/02/23/the-political-evolution-of-the-states-mapped-part-v/ The Political Evolution of the States, Mapped Part V]. ''Mad Politics: The Bizarre, Fascinating, and Unknown of American Political History''. Retrieved August 2, 2021.</ref> his colleague Wheeler was a staunch [[non-interventionist]], as was Montana's U.S. representative [[Jeannette Rankin]], the only member of Congress to vote against U.S. entry into the war.
Murray opposed the 1947 [[Taft-Hartley Act]] which amended the National Labor Relations Act and restricted the powers of [[labor union]]s,<ref name=archives/> voting against Senate passage<ref>[https://www.govtrack.us/congress/votes/80-1947/s56 S 1126. PASSAGE.]. ''GovTrack.us''. Retrieved August 2, 2021.</ref> as well as overriding President [[Harry S. Truman]]'s veto of the bill.<ref>[https://www.govtrack.us/congress/votes/80-1947/s86 HR 3020. PASSAGE OVER THE PRESIDENT'S VETO.]. ''GovTrack.us''. Retrieved August 2, 2021.</ref>